Gene information
Official symbol ESR1
Official full name estrogen receptor 1
Gene type protein-coding gene
Chromosome6q25.1-q25.2
Alias symbolNR3A1; Era; ER-alpha
Previous symbolESR
Gene familyNuclear hormone receptors
Resources
Entrez Gene 2099
HGNC HGNC:3467
Ensembl ENSG00000091831
Vega OTTHUMG00000016103
UCSC uc003qom.5
GO terms: 87 records
GO Description Category LogP Number of genes Detail
GO:0000791 euchromatin GO Cellular Components -1.42720730 3 More
GO:0001221 transcription coregulator binding GO Molecular Functions -4.88806294 16 More
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001763 morphogenesis of a branching structure GO Biological Processes -11.2402819 31 More
GO:0002009 morphogenesis of an epithelium GO Biological Processes -21.4354199 71 More
GO:0002064 epithelial cell development GO Biological Processes -8.05661081 27 More
GO:0005496 steroid binding GO Molecular Functions -8.57765300 12 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007548 sex differentiation GO Biological Processes -7.13021119 33 More
GO:0008134 transcription factor binding GO Molecular Functions -5.50998540 50 More
GO:0008202 steroid metabolic process GO Biological Processes -19.3229835 29 More
GO:0008283 cell population proliferation GO Biological Processes -17.2298624 68 More
GO:0008289 lipid binding GO Molecular Functions -15.8223476 88 More
GO:0008584 male gonad development GO Biological Processes -2.74541064 14 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009755 hormone-mediated signaling pathway GO Biological Processes -4.05849698 16 More
GO:0010517 regulation of phospholipase activity GO Biological Processes -7.06832255 9 More
GO:0010518 positive regulation of phospholipase activity GO Biological Processes -7.78358420 9 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010863 positive regulation of phospholipase C activity GO Biological Processes -6.38368268 7 More
GO:0016922 nuclear receptor binding GO Molecular Functions -4.35310017 9 More
GO:0019900 kinase binding GO Molecular Functions -6.03057706 62 More
GO:0019901 protein kinase binding GO Molecular Functions -6.66055444 59 More
GO:0022612 gland morphogenesis GO Biological Processes -7.35048069 19 More
GO:0030522 intracellular receptor signaling pathway GO Biological Processes -2.78567165 7 More
GO:0030850 prostate gland development GO Biological Processes -4.21089449 9 More
GO:0030855 epithelial cell differentiation GO Biological Processes -14.2408795 69 More
GO:0030879 mammary gland development GO Biological Processes -8.79064244 23 More
GO:0031334 positive regulation of protein-containing complex assembly GO Biological Processes -8.84926570 16 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0032355 response to estradiol GO Biological Processes -15.3711017 31 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0034121 regulation of toll-like receptor signaling pathway GO Biological Processes -7.06389205 16 More
GO:0035239 tube morphogenesis GO Biological Processes -44.2569269 123 More
GO:0035265 organ growth GO Biological Processes -9.67739919 20 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0042445 hormone metabolic process GO Biological Processes -9.53279610 17 More
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO Biological Processes -8.71585030 18 More
GO:0043254 regulation of protein-containing complex assembly GO Biological Processes -7.63830100 21 More
GO:0043433 negative regulation of DNA-binding transcription factor activity GO Biological Processes -10.6964949 32 More
GO:0043627 response to estrogen GO Biological Processes -7.69647850 16 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0046546 development of primary male sexual characteristics GO Biological Processes -2.71532895 14 More
GO:0046661 male sex differentiation GO Biological Processes -3.36897940 17 More
GO:0048145 regulation of fibroblast proliferation GO Biological Processes -11.1167439 21 More
GO:0048511 rhythmic process GO Biological Processes -10.3377021 38 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048608 reproductive structure development GO Biological Processes -16.4007448 61 More
GO:0048729 tissue morphogenesis GO Biological Processes -31.7796969 96 More
GO:0048732 gland development GO Biological Processes -26.3979320 74 More
GO:0048754 branching morphogenesis of an epithelial tube GO Biological Processes -10.2965313 26 More
GO:0048863 stem cell differentiation GO Biological Processes -16.2106470 36 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051117 ATPase binding GO Molecular Functions -1.78321252 4 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0060135 maternal process involved in female pregnancy GO Biological Processes -5.36863544 12 More
GO:0060147 regulation of post-transcriptional gene silencing GO Biological Processes -6.75865733 12 More
GO:0060191 regulation of lipase activity GO Biological Processes -10.2745708 13 More
GO:0060193 positive regulation of lipase activity GO Biological Processes -9.32996784 11 More
GO:0060443 mammary gland morphogenesis GO Biological Processes -4.29648227 9 More
GO:0060444 branching involved in mammary gland duct morphogenesis GO Biological Processes -2.72529058 5 More
GO:0060512 prostate gland morphogenesis GO Biological Processes -4.25041921 7 More
GO:0060560 developmental growth involved in morphogenesis GO Biological Processes -3.88675190 15 More
GO:0060562 epithelial tube morphogenesis GO Biological Processes -17.7630248 53 More
GO:0060688 regulation of morphogenesis of a branching structure GO Biological Processes -6.83160707 8 More
GO:0060740 prostate gland epithelium morphogenesis GO Biological Processes -4.51081372 7 More
GO:0060749 mammary gland alveolus development GO Biological Processes -3.03478521 5 More
GO:0060964 regulation of miRNA-mediated gene silencing GO Biological Processes -7.13447853 12 More
GO:0060966 regulation of gene silencing by RNA GO Biological Processes -6.64085561 12 More
GO:0061138 morphogenesis of a branching epithelium GO Biological Processes -11.1441029 30 More
GO:0061180 mammary gland epithelium development GO Biological Processes -3.92752553 10 More
GO:0061377 mammary gland lobule development GO Biological Processes -3.03478521 5 More
GO:0061458 reproductive system development GO Biological Processes -16.2516665 61 More
GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding GO Molecular Functions -8.00802452 40 More
GO:0062207 regulation of pattern recognition receptor signaling pathway GO Biological Processes -5.69211704 17 More
GO:0071383 cellular response to steroid hormone stimulus GO Biological Processes -3.35454241 16 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0071407 cellular response to organic cyclic compound GO Biological Processes -19.6857751 39 More
GO:0140297 DNA-binding transcription factor binding GO Molecular Functions -6.94737226 46 More
GO:1900274 regulation of phospholipase C activity GO Biological Processes -6.23203613 7 More
GO:1900368 regulation of post-transcriptional gene silencing by RNA GO Biological Processes -6.88005887 12 More
GO:1902532 negative regulation of intracellular signal transduction GO Biological Processes -29.4927428 92 More
GO:1905330 regulation of morphogenesis of an epithelium GO Biological Processes -7.22524154 15 More
GO:2000241 regulation of reproductive process GO Biological Processes -4.23306387 21 More
KEGG pathways: 8 records
KEGG Description Category LogP Number of genes Detail
hsa01522 Endocrine resistance KEGG Pathway -4.64858532 8 More
hsa04915 Estrogen signaling pathway KEGG Pathway -2.87451539 7 More
hsa04917 Prolactin signaling pathway KEGG Pathway -3.17844000 10 More
hsa04919 Thyroid hormone signaling pathway KEGG Pathway -4.89554233 17 More
hsa04961 Endocrine and other factor-regulated calcium reabsorption KEGG Pathway -2.44368714 4 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05207 Chemical carcinogenesis - receptor activation KEGG Pathway -7.05448873 28 More
hsa05224 Breast cancer KEGG Pathway -6.01672252 21 More
Drug-Gene interaction
view
Related drugs: 194 records
Drug name Interaction type Source PMID View
1-hydroxy-6-(4-hydroxy-phenyl)-1-phenyl-hexan-3-one (enantiomeric mix) DTC 20430632 view
3r14s-ochratoxin a DTC view
4-methylbenzoic acid methyl ester DTC view
4-nonylphenol DTC view
4-triethylgermylphenol DTC 23214428 view
abemaciclib PharmGKBFDA view
acetochlor DTC view
acolbifene modulator ChemblInteractionsTTD view
acrylamide DTC view
afimoxifene modulator DTCChemblInteractionsTTD 203343681584612224805199 view
alachlor DTC view
alfadex DTC view
alfatradiol DTC view
aloe-emodin DTC view
alpelisib PharmGKBFDA view
anastrozole ClearityFoundationBiomarkersPharmGKBFDA view
apigenin DTC view
arsanilic acid DTC view
arzoxifene TdgClinicalTrialTTD view
azd-9496 TTDOncoKB view
bazedoxifene agonistantagonist TdgClinicalTrialTTD 15535430 view
bazedoxifene acetate modulator ChemblInteractions view
benzethonium chloride DTC view
benzododecinium chloride DTC view
bisphenol a DTC view
bithionol DTC view
boric acid DTC view
brilanestrant antagonist ChemblInteractionsTTD view
cadmium dichloride DTC view
camphor DTC view
captan DTC view
catechol DTC view
cenestin ligand TTD view
cetrimonium bromide DTC view
chembl1222035 DTC 20659801 view
chembl1432305 DTC view
chembl1523215 DTC view
chembl1579130 DTC view
chembl184450 DTC view
chembl195515 DTC 20334372 view
chembl2071180 DTC 22647217 view
chembl221047 DTC 17432842 view
chembl2313444 DTC 23214428 view
chembl2313445 DTC 23214428 view
chembl259327 DTC view
chembl329673 DTC view
chembl354663 DTC view
chembl384441 DTC view
chembl503990 DTC view
chembl85826 DTC view
chf4227 modulator ChemblInteractionsTTD view
chloranil DTC view
chlorotrianisene agonist DTCTdgClinicalTrialTENDTTD 687293717236558117523522307235 view
cholecalciferol DTC view
cisplatin PharmGKB 21430602 view
clomiphene agonistantagonist TdgClinicalTrialTENDTTD 19761360183204351982129520379036200914982011412170558201587892511752352 view
clomiphene citrate modulator ChemblInteractions view
coumestrol DTC view
cumene hydroperoxide DTC view
cyclofenil TTD view
dactinomycin DTC view
daidzein DTC 16038533 view
danazol agonist DTCTdgClinicalTrialTENDTTD 75405784039467117523522326286 view
daunorubicin hydrochloride DTC view
desogestrel agonist TdgClinicalTrialTEND 1083619977502842175153 view
dichlorophen DTC view
dienestrol agonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 1527661736223779048584955871611752352333498718976723 view
dienogest TdgClinicalTrial view
diethylstilbestrol agonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 1732086826408814173176691730837317306201117523522038780317314305 view
diethylstilbestrol diphosphate agonist ChemblInteractionsTTD view
diethylstilbestrol dipropionate DTC view
docetaxel PharmGKBFDA view
domiphen bromide DTC view
doxorubicin hydrochloride DTC view
doxycycline PharmGKB 24185512 view
droloxifene modulator ChemblInteractions view
elacestrant TTD view
endosulfan DTC view
endoxifen DTCClearityFoundationClinicalTrialTTD 24805199 view
eribulin PharmGKBFDA view
estetrol TTD view
estradiol agonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 2033436820659801171386522587948516038533238841152011412117523521712591316520733249718151956161924805199 view
estradiol acetate agonist ChemblInteractions view
estradiol cypionate agonist ChemblInteractions view
estradiol valerate agonist ChemblInteractions view
estriol agonist TdgClinicalTrialTENDTTD 201141211752352 view
estrogen TdgClinicalTrialTTD view
estrogens, conjugated agonist ChemblInteractions view
estrogens, conjugated synthetic a agonist ChemblInteractions view
estrogens, esterified agonist ChemblInteractions view
estrone agonist DTCTdgClinicalTrialChemblInteractionsTENDTTD 20114121254719211752352 view
estropipate agonist ChemblInteractionsTTD 1713865220114121175235217125913 view
ethinyl estradiol agonist ChemblInteractions 1712437719434891170955911713865219237207117523521712591317142999 view
ethylenediamine DTC view
etonogestrel agonist TdgClinicalTrialTEND 1713928417016423 view
everolimus PharmGKBFDA view
exemestane PharmGKBFDA 26536870 view
fenretinide DTC view
fispemifene modulator TdgClinicalTrialChemblInteractions view
fulvestrant antagonist TALCDTCTdgClinicalTrialChemblInteractionsTENDCIViCPharmGKBTTDFDAOncoKB 201518462418551219133777264070121501859625879485125424031586585011922402121132371733718317275315198453861139891212080538241855101175235220621492 view
genistein DTC 1603853310592235 view
gentian violet DTC view
gestrinone antagonistagonist TTD view
glycitein DTC 16038533 view
goserelin PharmGKBFDA view
gossypol DTC view
gtx-758 agonist ChemblInteractionsTTD view
guggulsterone DTC view
guthion DTC view
gw7647 DTC view
hexachlorophene DTC 15081572 view
hydramethylnon DTC view
hydroxyprogesterone DTC view
icaritin TTD view
idoxifene modulator ChemblInteractions view
iodine TdgClinicalTrial view
ixabepilone PharmGKBFDA view
kaempferol DTC view
kepone DTC view
lapatinib PharmGKBFDA view
lasofoxifene negative modulatorantagonistagonist TdgClinicalTrialTTD 17456742 view
leflunomide PharmGKB 21174621 view
letrozole ClearityFoundationBiomarkersCIViCPharmGKBFDA 2552479826536870 view
levonorgestrel other/unknown TdgClinicalTrialTEND 125899401632524017634204166090131630796621791876156256516084894 view
ly2245461 modulator ChemblInteractions view
medroxyprogesterone acetate PharmGKB 9860300 view
megestrol TdgClinicalTrialTEND view
mercuric chloride DTC view
mestranol agonist TdgClinicalTrialChemblInteractionsTENDTTD 204975232052498111752352 view
methamphetamine PharmGKB 19386276 view
methiocarb DTC view
methoxsalen DTC view
methylisothiocyanate DTC view
methyltestosterone DTC 25012808 view
mitotane TTD 14579009 view
mk-6913 agonist TdgClinicalTrialChemblInteractions view
monoethanolamine DTC view
n-propyl bromide DTC view
neratinib PharmGKBFDA view
nordihydroguaiaretic acid DTC view
norelgestromin TdgClinicalTrial view
norgestimate agonist TdgClinicalTrialTEND 1467273125970022217515314670645 view
norgestrel TdgClinicalTrialTEND view
olaparib PharmGKBFDA view
orthotolidine DTC view
ospemifene agonistantagonistmodulator TdgClinicalTrialChemblInteractionsTTD 1525528416153821 view
oxymetholone DTC view
oxytetracycline hydrochloride DTC view
palbociclib CIViCPharmGKBFDA 25524798 view
palmitic acid DTC view
pentabromophenol DTC view
pertuzumab PharmGKBFDA view
phenazopyridine hydrochloride DTC view
phenolphthalein agonist DTC 3620717 view
phenylalanine DTC view
phenylmercuric acetate DTC view
polyestradiol phosphate agonist ChemblInteractions view
progesterone negative modulatorinhibitoragonist TdgClinicalTrialTEND 2615385917103262172037751711817319094096173413051741570911014241 view
promestriene TTD view
propachlor DTC view
propylparaben DTC view
propylpyrazoletriol agonist DTC view
protoapigenone DTC 16038533 view
puerarin DTC 16038533 view
pyrithione zinc DTC view
pyrogallol DTC view
quinestrol modulatoragonist TdgClinicalTrialChemblInteractionsTENDTTD 11752352171392841701642321075131 view
rad1901 TdgClinicalTrialChemblInteractions view
raloxifen TdgClinicalTrial view
raloxifene antagonistagonist DTCTdgClinicalTrialTENDPharmGKBTTDFDA 1047753520659801169514781050774310376571104189792754637310485477100684181877812411752352 view
resveratrol DTC 19496085 view
retinal DTC view
retinol DTC view
ribociclib PharmGKBFDA view
sivifene TdgClinicalTrial view
sr16234 antagonist TdgClinicalTrialChemblInteractions view
stanolone DTC 12676605 view
sulfentrazone DTC view
synthetic conjugated estrogens, b agonist ChemblInteractions view
tamoxifen agonistantagonist DTCClearityFoundationBiomarkersTdgClinicalTrialClearityFoundationClinicalTrialTENDCIViCPharmGKBTTDFDA 243980472418551220659801205127961190644120114122418551011752352167351201771346620621492 view
tamoxifen citrate modulator DTCChemblInteractions view
testosterone inhibitor DTC 160385331097392112676605 view
testosterone propionate DTC view
toremifene modulator TdgClinicalTrialTENDPharmGKBTTDFDA 1287088516595024117476281750389418279543170627211175235215369444165154781650376516917142 view
toremifene citrate modulator ChemblInteractions view
trastuzumab PharmGKBFDA view
triadimefon DTC view
triamterene DTC view
triphenylstannanol DTC view
tris(2,3-dibromopropyl)phosphate DTC view
vintafolide ClearityFoundationClinicalTrial view
zearalenone DTC view
zeranol DTC 19913605 view
ziram DTC view
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
NM_000125.4:c.453-397T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Li Y et al. Zhonghua Yi Xue Za Zhi. 2001
NM_000125.4:c.453-397T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Shearman AM et al. Jama. 2003
NM_000125.4:c.453-397T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Shearman AM et al. Circ Res. 2006
NM_000125.4:c.453-351A>G genomics myocardial infarction[diagnosis] myocardial infarction Roszkowska-Gancarz M et al. Clin Chim Acta. 2010
NM_000125.4:c.[453-397T>C;453-351A>G] genomics myocardial infarction[diagnosis] myocardial infarction Schuit SC et al. Jama. 2004
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